Promoter Binding Protein

The c-myc promoter binding protein (MBP-1) is a DNA binding protein which ne

gatively regulates the expression of the human c-myc gene. MBP-1 binds to a sequence which overlaps the binding site for the general transcription factor TBP, within the c-myc P2 promoter region. Since TBP binds in the minor groove,

In genetics, a promoter is a sequence of DNA to which proteins bind that ini

tiate transcription of a single RNA from the DNA downstream of it. This RNA may encode a protein, or can have a function in and of itself, such as tRNA, mRNA, or rRNA.

In Arabidopsis thaliana, microRNA156 (miR156) plays a role in regulating the

development of flowers and siliques by targeting members of the SQUAMOSA promoter binding protein-LIKE (SPL) gene family.

Probable guanine nucleotide exchange factor (GEF) which may activate RAB10.

Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed: 8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter.2 Publications

Proteins bind to specific sequences (usually) 5' to the TATA box to regulate

the efficiency of utilization of the promoter. These are frequently activators, but proteins that exert negative control are also being characterized. Examples of activator proteins Sp1: binds GGGGCGGGG = GC box

Squamosa promoter-binding-like protein 12 Gene names i: Name:SPL12. Ordered

Locus Names: At3g60030. ORF Names: T2O9.10. Organism i: Arabidopsis thaliana (Mouse-ear cress) Taxonomic identifier i: 3702 : Taxonomic lineage i › Eukaryota › Viridiplantae › Streptophyta › › Embryophyta › ...

Sequence-specific DNA and RNA binding proteins (e.g. promoters, gene regulat

ory proteins and transcription factors) are vital in normal cellular control and in disease states such as cancer and specific genetic diseases.

The function of SQUAMOSA PROMOTER-BINDING PROTEIN-BOX gene TaSPL14 in wheat

is similar to that of OsSPL14 in rice in regulating plant height, panicle length, spikelet number, and thousand-grain weight of wheat, but differs during tiller development. TaSPL14 may regulate spike development via ethylene-response gene EIN3-LIKE 1 (TaEIL1), ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR 2.11 (TaRAP2.11 ...

The effect of ang II on the binding of nuclear proteins to the regulatory AP

-1 site B, previously shown to mediate the high glucose-response of the TGF-beta 1 promoter, was studied by electrophoretic mobility shift assays. Results: Ang II enhanced the activity of the TGF-beta1 promoter fragment -453/+11 approximately 1.6-fold.

The promoter DNA sequence is customized by the researcher and the reporter g

ene DNA sequence codes for a protein with detectable properties such as firefly luciferase, Renilla luciferase or alkaline phosphatase. These genes produce enzymes only when the promoter of interest is activated.

We found that SPL7 (for SQUAMOSA promoter binding protein–like7) is essent

ial for this response of miR398. SPL7 is homologous to Copper response regulator1, the transcription factor that is required for switching between plastocyanin and cytochrome c6 in response to copper deficiency in Chlamydomonas reinhardtii.

The TATA-binding protein (TBP) is a general transcription factor that binds

specifically to a DNA sequence called the TATA box. This DNA sequence is found about 30 base pairs upstream of the transcription start site in some eukaryotic gene promoters.

PROMOTERS & TERMINATORS. A. Bacterial SAPPHIRE Sequence Analyser for the Pre

diction of Prokaryote Homology Inferred Regulatory Elements - is a neural network based classifier for σ70 promoter prediction in Pseudomonas (Reference: Coppens L & Lavigne R (2020) BMC Bioinformatics 21(1): 415).. 70ProPred - is a predictor for discovering sigma70 promoters based on combining multiple features ...

Junko Kyozuka, in Advances in Botanical Research, 2014. 7.2.2.2 SPL Transcri

ption Factor Enhances the Indeterminate Branch Phase in Maize and Rice. SQUAMOSA promoter binding protein (SPL) encodes a plant-specific transcription factor which binds to the promoter sequence of the SQUAMOSA-type MADS-box genes.The SPL genes were first reported in Antirrhinum (Klein, Saedler, & Huijser, 1996).

Two important transitions in shoot development—the juvenile-to-adult veget

ative transition and the vegetative-to-reproductive transition—are mediated by a group of genes targeted by miR156, SQUAMOSA promoter binding protein (SBP) genes.

Loss-of-function mutations in the gene encoding the DNA-binding protein woul

d result in little or no Cool expression. 11 b) You have discovered a protein X that binds DNA just downstream of the promoter sequence of the CYM gene. One of your colleagues suggests that, if the protein X is a transcription activator, loss-of-function mutations in ...

The murine G+C-rich promoter binding protein mGPBP is required for promoter-

specific transcription.

I'm trying to find promoters, in a bacterial genome for sigma 70 for example

. One way I tried was to, using blastn, query one of the motifs in the sigma 70 binding site, TTGACA, but it seems it's too short to find anything (using aquifex vf5 genome fasta file as the database).

Stasiv et al. (1994) reported the cloning of a cDNA encoding a c-myc promote

r-binding protein called IRLB. The predicted amino acid sequence contains a putative alpha-helical DNA binding region. Bacterially expressed protein was shown to bind to the ISRE (interferon-stimulated response element) of the c-myc promoter.

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The lack of the CHOP-RE prevents any activation of the IL-8 promoter by PGE

2 (Fig. 8B) and as well as IL-8 protein synthesis (Fig. 8C), thus clearly indicating that CHOP binding to its consensus sequence is a necessary event for IL-8 promoter up-regulation induced by PGE 2.

Lipopolysaccharide binding protein (LBP) function is dependent on circulatin

g LBP levels. Disturbance of LBP transcription regulation may influence the risk for clinical events. In a nested case-control study using a single nucleotide polymorphism haplotype tagging (tagSNP) approach, we assessed whether genetic variation in the LBP gene influences the risk for Gram-negative (GN) bacteremia ...

Squamosa promoter binding protein-like (SBP/SBP-Box) is a major family of pl

ant-specific TFs, which plays important roles in multiple processes involving plant growth and development. While some work has been done, there is a lot more that is yet to be discovered in the hexaploid wheat SBP (TaSBP) family.

Each C-myc promoter-binding protein Peptide and C-myc promoter-binding prote

in Protein is fully covered by our Guarantee+, to give you complete peace of mind and the support when you need it. Our C-myc promoter-binding protein Peptides and C-myc promoter-binding protein Proteins can be used in a variety of model species: Human.

This 66-kDa protein, designated the murine G+C-rich promoter binding protein

(mGPBP), can bind specifically to both the murine Adagene's MSPE and the nonhomologous human Topo IIα gene's G+C-rich promoter, as revealed by competitive gel mobility shift assays.

I have an idea to identify the transcription factors binding to a specific D

NA region. I don't have any transcription factor candidate, only what I have is a potential promoter region of a gene.

Eukaryotic promoter elements. The protein which interacts with the initiator

and TATA box is known as the TATA-box binding protein (TBP), which recognizes not only the core promoter of protein genes, but also RNA promoters (Section I). It is a subunit of the general transcription factor TFIID.

Transgenic SCA17 mice express full-length human TATA-box binding protein (hT

BP) cDNA with either 71 or 105 CAG/CAA repeats driven by the PrP promoter. The mice develop an early ataxic phenotype with dramatically reduced lifespan.

TBP (TATA-Box Binding Protein) is a Protein Coding gene. Diseases associated

with TBP include Spinocerebellar Ataxia 17 and Parkinson Disease, Late-Onset.Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and RNA Polymerase I Promoter Escape.Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and ...

TATA-binding protein works as part of a larger transcription factor, TFIID,

that starts the process of transcription. After it binds to the promoter, it recruits additional transcription factors. TFIIB, shown at the top here from PDB entry 1vol, binds next.

Promoters control the binding of RNA polymerase and transcription factors. S

ince the promoter region drives transcription of a target gene, it therefore determines the timing of gene expression and largely defines the amount of recombinant protein that will be produced. Many common promoters. like CMV, EF1A, and SV40 promoters, are always active and thus referred to as constitutive promoters.

A promoter is a region of DNA where transcription of a gene is initiated. Pr

omoters are a vital component of expression vectors because they control the binding of RNA polymerase to DNA. RNA polymerase transcribes DNA to mRNA which is ultimately translated into a functional protein.

anti-GC-Rich promoter binding protein 1 Antibodies GPBP1 was originally isol

ated by subtractive hybridization of cDNAs expressed in atherosclerotic plaques with a thrombus, and was found to be expressed only in vascular smooth muscle cells.

GC-Rich promoter binding protein 1 Proteins GPBP1 was originally isolated by

subtractive hybridization of cDNAs expressed in atherosclerotic plaques with a thrombus, and was found to be expressed only in vascular smooth muscle cells.

Promoters in Groups of Genes. open in new window AlignACE - a program which

finds sequence elements conserved in a set of DNA sequences from Church lab Download program open in new window Here; open in new window CREME - Cis-REgulatory Module Explorer 2.0; open in new window Gibbs motif sampler; open in new window MEME - The MEME/MAST System; open in new window MotifSampler - finds motifs in ...

The binding interfaces of (most) proteins in the database are inferred from

the collection of protein-DNA complexes described in 3D-footprint. Athamap AthaMap provides a genome-wide map of potential transcription factor and small RNA binding sites in Arabidopsis thaliana.

Background SQUAMOSA PROMOTER-BINDING PROTEIN-BOX gene OsSPL14 from rice is e

valuated as the major gene for ideal plant architecture consisting of few unproductive tillers, more grains per spike ...

15. The binding of CRP (cAMP receptor protein of E. coli) to DNA in the lac

operon: A) assists RNA polymerase binding to the lac promoter. B) is inhibited by a high level of cAMP. C) occurs in the lac repressor region. D) occurs only when glucose is present in the growth medium. E) prevents the repressor from binding to the lac operator.

The transcription factor ZBTB7A (zinc finger and BTB domain‐containing pro

tein 7A) has been shown or predicted to repress transcription of genes involved in proliferation and differentiation by interacting with other factors, several of which have known or predicted binding sites near or at the ALOX5 core promoter. These proteins include Sp1 ...

This promoter set allows us to determine the correspondence between the abso

lute numbers of mRNA molecules or protein products and the predicted promoter binding energies measured in energy units. These binding sites adhere on average to the predicted level of gene expression over orders of magnitude in constitutive gene expression, to within a ...

This result shows that the binding of FleQ to one binding site is independen

t of protein occupancy at the other binding site. The 19 bases of the FleQ boxes are not equally involved in the binding of FleQ but an intact repeated sequence seems to be required for the binding of FleQ to the pelA promoter.

Insulators are needed to prevent an enhancer (or silencer) from activating (

or inhibiting) another nearby gene that should be affected. They are sequences between the enhancer (or silencer) and the promoter or a gene or a cluster of genes. Eukaryotic insulators have a CCCTC nucleotide site which bind proteins called CCCTC binding factors (CTCF).

A promoter is a regulatory region of DNA located upstream (towards the 5' re

gion) of of a gene, providing a control point for regulated gene transcription.. The promoter contains specific DNA sequences that are recognized by proteins known as transcription factors. These factors bind to the promoter sequences, recruiting RNA polymerase, the enzyme that synthesizes the RNA from the coding ...

Mounting evidence indicates that both α-enolase (ENO1) and Myc promoter-bin

ding protein-1 (MBP-1) also played pivotal roles in tumorigenesis, although as antagonists. ENO1 is involved in cell growth, hypoxia tolerance and autoimmune activities besides its major role in the glycolysis pathway.

GPBP1, GC-rich promoter binding protein 1 Vertebrate Orthologs 9 Human Ortho

log GPBP1, GC-rich promoter binding protein 1 Orthology source: HomoloGene, HGNC Synonyms GPBP, SSH6, VASCULIN Links HGNC:29520 ...

The Poly(C) Motif in the Proximal Promoter Region of the D Site-Binding Prot

ein Gene (Dbp) Drives Its High-Amplitude Oscillation. Mol Cell Biol. 2019 Aug 15;39(16)) Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology ...

1) Core promoter (TATA/CAAT box) - RNA pol II binding site 2) Promoter proxi

mal elements - binding of TFs that allow RNA pol to bind to core promoters - 100-200 bps upstream of core promoter 3) Enhancers - bind to activator proteins that will increase rate of transcription 4) Silencers - bind to repressor proteins that will decrease rate of ...